Classification: BIOLOGICAL SCIENCES (Biophysics and Computational Biology) Sequential eviction of crowded nucleoprotein complexes by the RecBCD molecular motor
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Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor.
In physiological settings, all nucleic acids motor proteins must travel along substrates that are crowded with other proteins. However, the physical basis for how motor proteins behave in these highly crowded environments remains unknown. Here, we use real-time single-molecule imaging to determine how the ATP-dependent translocase RecBCD travels along DNA occupied by tandem arrays of high-affin...
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Department of Physics and b Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA; Molecular and Computational Biology Program, Departments of Biological Sciences and Chemistry, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA *Email...
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تاریخ انتشار 2017